Which neurological condition is associated with the development of plaque and tangles in the brain?

Alzheimer's disease is associated with the development of plaque and tangles in the brain. These plaques are primarily made up of amyloid-beta protein deposits, and the tangles consist of tau protein that has become hyperphosphorylated. The accumulation of these abnormal proteins disrupts cell communication and triggers inflammatory responses, leading to the death of brain cells. This neurodegenerative process is a hallmark of Alzheimer’s disease and is linked to the cognitive and memory deficits characteristic of the condition. The presence of these plaques and tangles is an important aspect of diagnosing and understanding the progression of Alzheimer's disease, distinguishing it from other neurological conditions that do not have this specific pathology.